8.15 – 9.15

Session I: Basic, Translational – ENS

Vorsitz: G. Mazzuoli-Weber (Hannover)

8.15 – 8.30
Enteric nerve-activating properties of fecal supernatants from irritable bowel syndrome patients with diarrhea
L Ridzal, A Annaházi, M Schemann, H Luksch, T Frieling, R Róka, O Inczefi, P Bacsur, D Bajcsi, M Neunlist, V Theodorou (München, Krefeld, Szeged - HUN, Nantes - FRA, Toulouse - FRA)

8.30 – 8.45
LGR/R-spondin1 signaling - familiar players with unfamiliar functions in postnatal ENS maturation
*M Scharr, S Scherer, P Neckel (Tübingen)

8.45 – 9.00
Enteric neural progenitor cells and the aging ENS
P Neckel, S Scherer, M Schar (Tübingen)

9.00 – 9.15
The human enteric nervous system in gastroschisis
*N Schlecht, S Scherer, U Mattheus, M Scharr, P Neckel (Tübingen)

9.15 – 10.00

Preisvortrag Forschungspreis Neurogastroenterologie

Vorsitz: T. Frieling (Krefeld)

9.15 – 9.30
Vorstellung der Stiftung und des Preises
T Frieling (Krefeld)

9.30 – 10.00
Significance of the enteric nervous system in Parkinson‘s disease
F Cossais (Kiel)

10.30 – 11.45

Session II: Basic, Translational - Motility, Cancer

Vorsitz: S. Scherer (Tübingen)

10.30 – 10.45
Recruitment of mechanosensitive enteric neurons in the guinea pig gastric fundus is dependent on the ganglionic stretch level K Elfers, S Mayr, G Mazzuoli-Weber (Hannover)

10.45 – 11.00
Sphingosine-1-phosphate receptors: Expression and function in the murine gastric fundus
R Patejdl, V Wendel, (Erfurt)

11.00 – 11.15
Spatial transcriptomic analysis of sensory neurons in murine pancreatic cancer reveals a potential role for neuron-mediated immune suppression in the tumor microenvironment
K Cifcibasi, C Mota Reyes, R Istvanffy, M Kießler, H Asimgil, M Ekizce, M Gokalp, G O Ceyhan, I E Demir (München, Istanbul - TUR)

11.15 – 11.30
Innervation at acinar-to-ductal metaplasia stage of pancreatic ductal adenocarcinoma
A Dogruöz, R Istvanffy, H Einwächter, G O Ceyhan, I E Demir, (München, Istanbul - TUR)

11.30 – 11.45
IL-1R signaling drives enteric glia-macrophage interactions in colorectal
Lies van Baarle, Veronica De Simone, Linda Schneider, Sneha Santhosh, Saeed Abdurahiman, Francesca Biscu, Reiner Schneider, Lisa Zanoletti, Sara Verbandt, Zedong Hu, Michelle Stakenborg, Bo-Jun Ke, Balbina García-Reyes, Jonas Henn, Marieta Toma, Maxime Vanmechelen, Frederik De Smet, Sales Ibiza, Sabine Tejpar, Sven Wehner, Gianluca Matteoli (Leuven - BEL, Bonn, Antwerpen - BE, Melbourne - AUS, Edinburgh - UK, Pavia - IT)

11.45 – 12.45

Session III: Basic, Translational - Inflammation

Vorsitz: H. Aziz-Kalbhenn (Darmstadt)

11.45 – 12.00
Neuroprotective effect of a rice bran extract against depression associated with experimental ulcerative colitis
M T Khayyal, W Wadie, E A Abdlel Haliem, S S Mohamed, H M Shendy, A Helal, O Galal (Kairo - EGY)

12.00 – 12.15
The anti-inflammatory effect of STW 5 in experimental colitis is associated with regulation of dysbiosis induced by DSS
M T Khayyal, S S Mohamed, N F Abdelwahab, O Kelber, S Rabini, H Aziz-Kalbhenn (Kairo - EGY, Darmstadt)

12.15 – 12.30
Transcriptional profiling of the enteric nervous system during intestinal inflammation
C Klose (Berlin)

12.30 – 12.45
Deciphering the role of the Cx3cl1-Cx3cr1 axis in modulating pain perception in pancreatitis mouse models
I H Gürcinar, O Safak, S Tokalov, D Jungwirth, P Gärtner, A Dogruoz, H Friess, G O Ceyhan, R Istvannfy, I E Demir (München)

13.45 – 15.45

Mitgliederversammlung

A. Stengel (Tübingen/Berlin), R. Patejdl (Erfurt), M. Goebel-Stengel (Sigmaringen/Tübingen)

16.15 – 18.00

Symposium on Neurogastroenterology - 20 years Foundation of Neurogastroenterology

Vorsitz: P. Enck (Berlin), M. Schemann (Freising)

16.15 – 16.20
Introduction
P Enck (Berlin)

16.20 – 16.40
Use of human gut samples in translational neurogastroenterology
F Christofi (Columbus, USA)

16.40 – 17.00
Relation between pathophysiology and symptoms in functional dyspepsia
J Tack (Leuven, BEL)

17.00 – 17.20
Drug discovery in functional gut diseases
P Wade (Philadelphia, USA)

17.20 – 17.40
Microbiota-gut-brain interactions may contribute to pathophysiology in chronic multi-symptom illness
M Curras-Collazo (Riverside, USA)

17.40 – 18.00
Sharing resources during lean times: How hibernators and their gut symbionts work together during winter fasting
H Carey (Sacramento, USA)

9.00 – 10.30

Session IV: Clinical – Experimental

Vorsitz: P. Neckel (Tübingen)

9.00 – 9.15
Impact of costly visceral pain avoidance on pain-related fear extinction
F Labrenz, A Kalenbach, S Elsenbruch, A Icenhour, (Bochum, Essen)

9.15 – 9.30
Effects of anesthesia on neural mechanisms of visceral pain processing and pain-related memory processes - an ongoing fMRI study
K Koch, S Elsenbruch, M Adamzik, A Wolf, W Weber, A Icenhour (Bochum)

9.30 – 9.45
Food intake alters the plasma levels of biomarkers related to Alzheimer‘s disease and neurodegeneration dependent on the meal composition
H Huber, N J Ashton, H Kvartsberg, F Gonzalez-Ortiz, A Schieren, L Weinhold, M Schmid, M Coenen, K Blennow, P Stehle, H Zetterberg, M-C Simon (Bonn, Göteborg - SWE)

9.45 – 10.00
Intraabdominal pressure is related to gastric transport function in stroke patients R Patejdl, M Lindner, M Wittstock (Erfurt) 10.00 – 10.15 Correlation of intratumoral mast cell quantity with psychosocial distress in patients with pancreatic cancer - The PancStress study
R Göß, A Sitte, T Tüfekçi, I Pergolini, P L Pfitzinger, E Salvo-Romero, C Mota Reyes, S Tokalov, O Safak, M Stengel-Goebel, G Mazzuoli-Weber, A Stengel, M Erkan, H Friess, R Istvanffy, G O Ceyhan, E Demir, I E Demir (München, Istanbul - TUR, Barcelona - ESP, Tübingen, Hannover, Berlin)

10.15 – 10.30
Insights regarding the development of duplications of the alimentary tract and the enteric nervous system - Overview and analysis with modern histology in a rare case
S Scherer, P Neckel, M Scharr, S W Warmann, M Schunn, J Hilberath, J Fuchs (Tübingen)

11.00 – 12.00

Session V: Clinical - Phytotherapeutics

Vorsitz: M. Goebel-Stengel (Sigmaringen/Tübingen)

11.00 – 11.15
What is behind the use of marshmallow root extract for symptomatic relief of mild gastrointestinal discomfort?
G A Bonaterra, J Schmitt, N Seller, O Kelber, H Aziz-Kalbhenn, K Bedal, R Kinscherf (Darmstadt, Marburg)

11.15 – 11.30
Effect of myrrh, chamomile flower extract, and coffee charcoal in the treatment of irritable bowel syndrome patients with intestinal barrier dysfunction as detected by confocal laser endomicroscopy
M Bittel, S Weyrauch, M-L Groh, J Langhorst (Bamberg)

11.30 – 11.45
Improvement of dyspeptic symptoms and quality of life by the Rikkunshito extract product YamatoGast from Japanese Kampo medicine: Results of a prospective non-interventional study in Germany
H Reißenweber-Hewel, C Pehl, S Cameron, J Thomsen, K Röschmann-Doose (München, Vilsbiburg, Göttingen, Hohenlockstedt)

11.45 – 12.00
Gender gap in the therapy of functional gastro-intestinal diseases? Data for a herbal medicinal product
J Worbs, O Kelber, E Raskopf, K Shah-Hosseini, K Nieber, K Kraft (Jena, Darmstadt, Köln, Leipzig, Rostock)

12.00

Verabschiedung

M. Goebel-Stengel (Sigmaringen/Tübingen), R. Patejdl (Erfurt), A. Stengel (Tübingen/Berlin)